Aesthet Surg J. 2010 Nov-Dec;30(6):838-42. doi: 10.1177/1090820X10386364.
Clinical applications of mesenchymal stem cells in soft tissue augmentation.
1Division of Plastic and Reconstructive Surgery, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA.
Based on a variety of preclinical studies showing that mesenchymal stem cells (MSC) play a significant role in tissue repair and homeostasis, MSC have rapidly moved into a phase of clinical trials investigating their efficacy as a cell-based therapeutic modality for a diverse group of applications. An emerging body of evidence shows that in addition to being a progenitor cell population with self-renewing and multipotent differentiation capabilities, MSC have unique immunomodulatory properties, making them even more attractive for regenerative medicine. Emerging discoveries in stem cell biology have revealed a multitude of mechanisms through which MSC could potentially augment the current techniques in aesthetic surgery. In this article, the authors review the clinical advances in cell-based therapies relevant to aesthetic surgery, including tissue augmentation,rejuvenation, and regeneration.
Keywords: mesenchymal stem cells, fat grafting, cosmetic augmentation, immune modulation