J Pharmacol Sci. 2014;126(4):293-301. doi: 10.1254/jphs.14R10CP. Epub 2014 Nov 18.
Therapeutic potential of human adipose-derived stem cells in neurological disorders.
1Department of Pharmacology, College of Medicine, Neuroscience Research Institute, Gachon University, Korea
Stem cell therapy has been noted as a novel strategy to various diseases including neurological disorders such as Alzheimer’s disease,Parkinson’s disease, stroke, amyotrophic lateral sclerosis, and Huntington’s disease that have no effective treatment available to date. Theadipose-derived stem cells (ASCs), mesenchymal stem cells (MSCs) isolated from adipose tissue, are well known for their pluripotency with the ability to differentiate into various types of cells and immuno-modulatory property. These biological features make ASCs a promising source for regenerative cell therapy in neurological disorders. Here we discuss the recent progress of regenerative therapies in various neurological disorders utilizing ASCs.
Keywords: neurological disorder, adipose-derived stem cell (ASC), Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD)
Neurodegener Dis. 2014;13(2-3):99-102. doi: 10.1159/000355261. Epub 2013 Oct 23.
The therapeutic effects of human adipose-derived stem cells in Alzheimer’s disease mouse models.
1Department of Pharmacology, College of Medicine, Gachon University, Incheon, Korea.
Alzheimer’s disease (AD) is an irreversible neurodegenerative disease, still lacking proper clinical treatment. Therefore, many researchers have focused on the possibility of therapeutic use of stem cells for AD. Adipose-derived stem cells (ASCs), mesenchymal stem cells (MSCs) isolated from adipose tissue, are well known for their pluripotency and their ability to differentiate into multiple tissue types and have immune modulatory properties similar to those of MSCs from other origins. Because of their biological properties, ASCs can be considered for cell therapy and neuroregeneration. Our recent results clearly showed the therapeutic potential of these cells after transplantation into Tg2576 mice (an AD mouse model). Intravenously or intracerebrally transplanted human ASCs (hASCs) greatly improved the memory impairment and the neuropathology, suggesting that hASCs have a high therapeutic potential for AD.
PLoS One. 2012;7(9):e45757. doi: 10.1371/journal.pone.0045757. Epub 2012 Sep 26.
The preventive and therapeutic effects of intravenous human adipose-derived stem cells in Alzheimer’s disease mice.
1Department of Pharmacology, College of Medicine, Neuroscience Research Institute, MRC, Seoul National University, Seoul, South Korea.
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid plaques and neurofibrillary tangles accompanied by cognitive dysfunction. The aim of the present study was to elucidate preventive and therapeutic potential of stem cells for AD. Among stem cells, autologous human adipose-derived stem cells (hASCs) elicit no immune rejection responses, tumorigenesis, or ethical problems. We found that intravenously transplanted hASCs passed through the BBB and migrated into the brain. The learning, memory and pathology in an AD mouse model (Tg2576) mice greatly improved for at least 4 months after intravenous injection of hASC. The number of amyloid plaques and Aβ levels decreased significantly in the brains of hASC-injected Tg mice compared to those of Tg-sham mice. Here, we first report that intravenously or intracerebrally transplanted hASCs significantly rescues memory deficit and neuropathology, in the brains of Tg mice by up-regulating IL-10 and VEGF and be a possible use for the prevention and treatment of AD.